Hi,
Indeed we do not have built-in launch condition for .Net Framework 4.8.1. This improvement is already on our todo list and hopefully it will be available in a future version of Advanced Installer. When so we will update this forum thread.
In the meantime, as a workaround, you can simply copy the search condition from the "Prerequisites" view. And then just create a search in "Search" page that uses this registry location.
Finally create your own custom launch condition using the search result.

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Let me know if you need more details on this.
All the best,
Daniel
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